Exploratory experiment designed to discover new patterns targeting 7 mRNAs in ceRNA network in computational network analysis. Primary outcome: ceRNA network comprising 7 mRNAs, 41 miRNAs, and 46 lncRNAs
A comprehensive competing endogenous RNA (ceRNA) network was constructed by integrating multi-database miRNA target predictions with RNA expression correlation data. This analysis aimed to understand the regulatory relationships between long non-coding RNAs, microRNAs, and mRNAs in the context of cerebral microvascular dysfunction in early Alzheimer's disease. The network provides insights into post-transcriptional regulatory mechanisms.
Integration of miRNA target prediction databases with expression correlation analysis
Identification of regulatory ceRNA networks
Validated miRNA-target interactions with expression correlations
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