Proximity labeling approach combined with proteomics identified subcellular molecular architecture of spheroids in human postmortem brains, revealing abnormalities in protein turnover, cytoskeleton dy

Computational Score: 0.500 Price: $0.50 Alzheimer's disease human Status: extracted

What This Experiment Tests

Computational experiment designed to assess clinical efficacy targeting MTOR in human. Primary outcome: Proximity labeling approach combined with proteomics identified subcellular molecular architecture o

Description

Proximity labeling approach for spheroid proteome analysis in human postmortem brains

TARGET GENE

MTOR (Score: 0.419)

MODEL SYSTEM

human

ESTIMATED COST

TIMELINE

0 months

PATHWAY

PI3K/AKT/mTOR pathway

SOURCE

pmid_40065072

PRIMARY OUTCOME

Proximity labeling approach combined with proteomics identified subcellular molecular architecture of spheroids in human postmortem brains, revealing abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport.

Scoring Dimensions

Related Hypotheses (4)

APOE4-Specific Proteolytic Fragment Inhibition Therapy0.777

APOE-Dependent Autophagy Restoration0.877

Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericytes0.578

Metabolic Checkpoint Reprogramming via TREM2-mTOR Axis0.455

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