entity

trained immunity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about trained immunity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

5Hypotheses

1Analyses

1Outgoing

6Incoming

0Experiments

3Debates

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Outgoing (1)

Target	Relation	Type	Str
neurodegeneration	causes	disease	0.50

Incoming (6)

Source	Relation	Type	Str
C1Q	modulates	protein	0.95
BCG	associated_with	drug	0.80
C1Q	associated_with	gene	0.70
inflammatory epigenetic scars	causes	process	0.70
histone demethylase inhibitors	inhibits	drug	0.50
KDM1A inhibitors	inhibits	drug	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.712	neuroinflammation	What specific astrocyte-derived factors
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis	0.644	developmental neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.380	developmental neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.351	developmental neurobiology	Do perinatal immune challenges create pe