Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about tight junction integrity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CLDN5/ZO-1 complex | regulates | protein | 0.90 |
| endothelial CD2AP | associated_with | protein | 0.80 |
| cerebral microvascular endothelial cells | regulates | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| C1q-Alectinib Complexation Disrupts Tight Junction Integrity | 0.445 | molecular biology | Does Alectinib truly bind C1q directly w |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760
neurodegeneration | 2026-04-02 | 8 hypotheses Top: 0.800
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.73 · 2026-04-25
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
Hypotheses and analyses mentioning tight junction integrity in their description or question text
No additional research found