Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic protection: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GFAP | modulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Complement Cascade Inhibition Synaptic Protection | 0.867 | neurodegeneration | View |
| Neutral Sphingomyelinase-2 Inhibition for Synaptic Protectio | 0.844 | neurodegeneration | Lipid raft composition changes in synapt |
| Complement-Mediated Synaptic Protection | 0.580 | neurodegeneration | Neuroinflammation and microglial priming |
| Synaptic protection via microglial/complement normalization | 0.560 | neurodegeneration | Does the cancer-cystatin-C-TREM2 pathway |
| NFκB/C1Q SASP Modulation for Synaptic Protection | 0.534 | neurodegeneration | View |
| CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lip | 0.380 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| IL-33/ST2 Axis Augmentation for Synaptic Protection | 0.105 | neurodegeneration | Neuroinflammation Biomarker Panel for Ea |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| C1q neutralization experiment | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| scRNA-seq analysis of human atherosclerotic plaques | exploratory | Atherosclerosis | 0.900 | 0.00 | human atherosclerotic plaque s | proposed | N/A |
| Sevoflurane-induced neurotoxicity (SIN) model in rats | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| Machine learning-based identification of C1Q hub genes | exploratory | Atherosclerosis | 0.900 | 0.00 | Human bulk RNA sequencing data | proposed | N/A |
| Gene expression validation in apoE-/- mice | validation | Atherosclerosis | 0.850 | 0.00 | apoE-/- mice | proposed | N/A |
| ox-LDL treatment of RAW264.7 macrophages | exploratory | Atherosclerosis | 0.850 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| nSMase2 Inhibitor DPTIP Rescues Synaptic Density in APPswe/PS1deltaE9 | in_vivo | Alzheimer's disease | 0.803 | 0.74 | APPswe/PS1dE9 bigenic mice, 6- | proposed | $62,000 |
| Validation of hub genes in ox-LDL treated RAW264.7 macrophages | exploratory | Atherosclerosis | 0.800 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| Validation of hub genes in apoE-/- atherosclerotic mice | validation | Atherosclerosis | 0.800 | 0.00 | apoE-/- mice | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964] | Righes Marafiga J, Vu T, Bowlus J, Barab | Progress in neurobiology | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | Geroscience | 2026 | 0 |
| Robust characterization and interpretation of rare pathogenic cell populations f [PMID:41547856] | Zhang X, Yu Z, Hao G, Yao Q, Hu Y et al. | Nat Commun | 2026 | 0 |
| Structural signature of plasma proteins classifies the status of Alzheimer's dis [PMID:41760935] | Son A, Kim H, Diedrich JK, Bamberger C, | Nat Aging | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | GeroScience | 2026 | 0 |
| Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: se [PMID:41853292] | Zhai X, Lin X, Zhang L, Ren Y, Miao H, M | Frontiers in immunology | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Role of neuroinflammation in neurodegeneration development. [PMID:37433768] | Zhang W, Xiao D, Mao Q, Xia H | Signal transduction and target | 2023 | 0 |
| Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. [PMID:36890231] | Chen X, Firulyova M, Manis M, Herz J, Sm | Nature | 2023 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Microglia Function in the Central Nervous System During Health and Neurodegenera [PMID:28226226] | ["Colonna Marco", "Butovsky Oleg"] | Annual review of immunology | 2017 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 0 · Score: 0.66 · 2026-04-21
closed · Rounds: 0 · Score: 0.64 · 2026-04-21
Hypotheses and analyses mentioning synaptic protection in their description or question text
Score: 0.380 · lipidomics · 2026-04-26
This hypothesis proposes that CYP2J2-generated DHA epoxides act as endogenous LXRβ agonists, creating a synergistic mech
Score: 0.105 · neurodegeneration · 2026-04-18
## Mechanistic Overview IL-33/ST2 Axis Augmentation for Synaptic Protection starts from the claim that modulating not ye