Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about plasma GFAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Cognitive impairment | correlates_with | phenotype | 0.90 |
| Whole Brain Glucose Consumption | associated_with | phenotype | 0.88 |
| Alzheimer's Disease Progression | risk_factor_for | phenotype | 0.87 |
| Amyloid-β Burden | correlates_with | phenotype | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| plasma GFAP separates causal from compensatory states in: Bl | 0.321 | neurodegeneration | Blood-brain barrier permeability changes |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal gangli [PMID:40345829] | Shi, Sato, Takahashi, Ohno-Ohishi, Muray | Life science alliance | 2025 | 0 |
| The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegen [PMID:40468412] | Karunakaran DKP, Ley M, Guo J, Khatri A, | Molecular neurodegeneration | 2025 | 0 |
| AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal gangli [PMID:40345829] | Unknown | Life science alliance | 2025 | 0 |
| The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegen [PMID:40468412] | Karunakaran DKP, Ley M, Guo J, Khatri A, | Molecular neurodegeneration | 2025 | 0 |
| Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Ne [PMID:39441380] | Taheri M, Roghani M, Sedaghat R | Cellular and molecular neurobi | 2024 | 0 |
| Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Ne [PMID:39441380] | Taheri M, Roghani M, Sedaghat R | Cellular and molecular neurobi | 2024 | 0 |
| Dual-targeting of brain tumors with nanovesicles. [PMID:36816997] | Kianinejad N, Kwon YM | Bioimpacts | 2023 | 0 |
| Peripheral inflammation and blood-brain barrier disruption: effects and mechanis [PMID:33381913] | Huang X, Hussain B, Chang J | CNS Neurosci Ther | 2021 | 0 |
| Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encep [PMID:34804998] | Peng X, Luo Z, He S | Front Cell Infect Microbiol | 2021 | 0 |
| Blood-Brain Barrier Overview: Structural and Functional Correlation. [PMID:34912450] | Alahmari A | Neural Plast | 2021 | 0 |
| Peripheral inflammation and blood-brain barrier disruption: effects and mechanis [PMID:33381913] | Huang, Hussain, Chang | CNS neuroscience & therapeutic | 2021 | 0 |
| Novel NMDA-receptor antagonists ameliorate vanadium neurotoxicity. [PMID:32388602] | Ladagu AD, Olopade FE, Folarin OR, Elufi | Naunyn-Schmiedeberg's archives | 2020 | 0 |
| Novel NMDA-receptor antagonists ameliorate vanadium neurotoxicity. [PMID:32388602] | Ladagu AD, Olopade FE, Folarin OR, Elufi | Naunyn-Schmiedeberg's archives | 2020 | 0 |
| Protein misfolding and oxidative stress promote glial-mediated neurodegeneration [PMID:21414908] | Wang, Colodner, Feany | The Journal of neuroscience : | 2011 | 0 |
| Protein misfolding and oxidative stress promote glial-mediated neurodegeneration [PMID:21414908] | Unknown | The Journal of neuroscience : | 2011 | 0 |
| The blood-brain barrier in health and chronic neurodegenerative disorders. [PMID:18215617] | Zlokovic BV | Neuron | 2008 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning plasma GFAP in their description or question text
No additional research found