Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about integrated_stress_response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| MAPT | modulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| eIF2α Phosphorylation Imbalance Creates Integrated Stress Re | 0.896 | ALS | - |
| ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cort | 0.650 | Frontotemporal dementia | - |
| Chronic ISR Activation Represses Axonal Protein Synthesis in | 0.650 | Parkinson's disease | - |
| TOM/TIM Complex Disruption Triggering Mitochondrial Integrat | 0.622 | neurodegeneration | What upstream mechanisms cause TDP-43 to |
| Neuronal Integrated Stress Response Modulation | 0.526 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| TBK1 Loss Triggers eIF2α-Mediated Translational Repression T | 0.000 | ALS | What are the mechanisms by which microgl |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.624
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.726
neurodegeneration | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.66 · 2026-04-25
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-02
Hypotheses and analyses mentioning integrated_stress_response in their description or question text