Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HOMEOSTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HOMEOSTASIS |
| Key Genes/Proteins | ANXA1 |
Knowledge base pages for this entity
graph TD
HOMEOSTASIS["HOMEOSTASIS"]
Astrocytes["Astrocytes"] -->|"involved_in"| HOMEOSTASIS
Cell_Death["Cell Death"] -->|"involved_in"| HOMEOSTASIS
Autophagy["Autophagy"] -->|"involved_in"| HOMEOSTASIS
Ferroptosis["Ferroptosis"] -->|"involved_in"| HOMEOSTASIS
Inflammation["Inflammation"] -->|"regulates"| HOMEOSTASIS
Glycosylation["Glycosylation"] -->|"regulates"| HOMEOSTASIS
autophagy["autophagy"] -->|"regulates"| HOMEOSTASIS
Complement_System["Complement System"] -->|"participates in"| HOMEOSTASIS| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Autophagy | contributes_to | process | 0.92 |
| Cell Death | involved_in | process | 0.90 |
| Astrocytes | involved_in | cell_type | 0.90 |
| Autophagy | involved_in | process | 0.90 |
| Inflammation | associated_with | process | 0.90 |
| Integrated Stress Response | associated_with | pathway | 0.90 |
| Glycosylation | associated_with | process | 0.90 |
| Microglia | associated_with | cell_type | 0.85 |
| autophagy | regulates | process | 0.85 |
| Glycosylation | regulates | process | 0.85 |
| Ferroptosis | involved_in | process | 0.85 |
| Inflammation | regulates | process | 0.85 |
| ANXA1 | associated_with | protein | 0.85 |
| Pi3K/Akt | associated_with | pathway | 0.85 |
| NF-κB | associated_with | pathway | 0.85 |
| Ap-1 | associated_with | pathway | 0.85 |
| ANXA1 | maintains | protein | 0.70 |
| MTOR | regulates | protein | 0.70 |
| damaged organelles | regulates | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from E | 0.770 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| Critical Period Hypothesis: The Therapeutic Window Closes Wh | 0.640 | neurodegeneration | What is the therapeutic window between t |
| SCFA Deficiency Disrupts Microglial Homeostasis and Promotes | 0.558 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
| HDAC6 Inhibitor Therapy for Pan-Neurodegenerative Protein Ho | 0.450 | neurodegeneration | Comparative epigenetic signatures across |
| Branched-Chain Amino Acid Transamination Inhibition to Modul | 0.400 | metabolomics | Metabolomic signatures of neurodegenerat |
| TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeosta | 0.105 | neurodegeneration | Neuroinflammation Biomarker Panel for Ea |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty [PMID:40254847] | Meiying Song, Shanshan Zhang, Yuxin Gan | {'name': 'Journal of agricultu | 2025 | 0 |
| Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short [PMID:41473323] | Vrishali S. Salian, Vaishnavi Veerareddy | {'name': 'bioRxiv'} | 2025 | 0 |
| Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and [PMID:38377788] | Kalyanaraman B, Cheng G, Hardy M | Redox biology | 2024 | 0 |
| Short-chain fatty acids abrogate Japanese encephalitis virus-induced inflammatio [PMID:38869276] | Atreye Majumdar, Indira Priya Siva Venka | {'name': 'mBio', 'volume': '15 | 2024 | 0 |
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochim Biophys Acta Mol Basis | 2023 | 0 |
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochimica et biophysica acta. | 2023 | 0 |
| Regulation of SIRT1 and Its Roles in Inflammation. [PMID:35359990] | Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, | Frontiers in immunology | 2022 | 0 |
| SIRT1 and aging related signaling pathways. [PMID:32084459] | Chen C, Zhou M, Ge Y, Wang X | Mechanisms of ageing and devel | 2020 | 0 |
| NAD(+) metabolism governs the proinflammatory senescence-associated secretome. [PMID:30778219] | Unknown | Nat Cell Biol | 2019 | 0 |
| Sirt1 and the Mitochondria. [PMID:26831453] | Tang BL | Molecules and cells | 2016 | 0 |
| Rosiglitazone synergizes the neuroprotective effects of valproic acid against qu [PMID:24566814] | Mishra J, Chaudhary T, Kumar A | Neurotox Res | 2014 | 0 |
| Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone d [PMID:17398106] | Sinn DI, Kim SJ, Chu K | Neurobiol Dis | 2007 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HOMEOSTASIS in their description or question text