Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about gut microbiome dysbiosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | contributes_to | process | 0.85 |
| PARKINSON'S DISEASE | associated_with | disease | 0.80 |
| cognitive dysfunction | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TLR4 priming is the actionable driver in: How does gut micro | 0.753 | neurodegeneration | How does gut microbiome dysbiosis contri |
| plasma LPS-binding protein separates causal from compensator | 0.738 | neurodegeneration | How does gut microbiome dysbiosis contri |
| microglial inflammasome tone defines the therapeutic window | 0.720 | neurodegeneration | How does gut microbiome dysbiosis contri |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.710
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.753
neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.605
neurodegeneration | 2026-04-01 | 0 hypotheses
neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Iron and the Intestinal Microbiome. [PMID:40603801] | Li H | Adv Exp Med Biol | 2025 | 0 |
| Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP- [PMID:40958035] | Li Z, Sun X, Wang Y | Basic Res Cardiol | 2025 | 0 |
| Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] | Wang W, Wang Y, Wang F, Xie G, Liu S, Li | Phytomedicine : international | 2024 | 0 |
| Joint-specific memory, resident memory T cells and the rolling window of opportu [PMID:38600215] | Chang MH, Fuhlbrigge RC, Nigrovic PA | Nat Rev Rheumatol | 2024 | 0 |
| Oral Microbiome: A Review of Its Impact on Oral and Systemic Health. [PMID:39338471] | Rajasekaran JJ, Krishnamurthy HK, Bosco | Microorganisms | 2024 | 0 |
| Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] | Wang W, Wang Y, Wang F, Xie G, Liu S, Li | Phytomedicine : international | 2024 | 0 |
| Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662] | ["Zhang Di", "Jing Bei", "Chen Zhen-Ni", | CNS neuroscience & therapeutic | 2023 | 0 |
| Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081] | Park, Hwang, Lee, Jang, Jeong et al. | Frontiers in immunology | 2023 | 0 |
| The role of the microbiota in glaucoma. [PMID:37866106] | Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa | Molecular aspects of medicine | 2023 | 0 |
| Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081] | Unknown | Frontiers in immunology | 2023 | 0 |
| Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662] | ["Zhang Di", "Jing Bei", "Chen Zhen-Ni", | CNS neuroscience & therapeutic | 2023 | 0 |
| The role of the microbiota in glaucoma. [PMID:37866106] | Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa | Molecular aspects of medicine | 2023 | 0 |
| The role of Toll-like receptors and neuroinflammation in Parkinson's disease. [PMID:35668422] | ["Heidari Arash", "Yazdanpanah Niloufar" | Journal of neuroinflammation | 2022 | 0 |
| Pyroptosis in acute pancreatitis and its therapeutic regulation. [PMID:35687256] | Al Mamun A, Suchi SA, Aziz MA | Apoptosis | 2022 | 0 |
| Microglia in multiple sclerosis: Protectors turn destroyers. [PMID:35882229] | Yong | Neuron | 2022 | 0 |
| Microglia in multiple sclerosis: Protectors turn destroyers. [PMID:35882229] | Unknown | Neuron | 2022 | 0 |
| The role of Toll-like receptors and neuroinflammation in Parkinson's disease. [PMID:35668422] | ["Heidari Arash", "Yazdanpanah Niloufar" | Journal of neuroinflammation | 2022 | 0 |
| TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory sign [PMID:33057840] | ["Ciesielska A", "Matyjek M", "Kwiatkows | Cellular and molecular life sc | 2021 | 0 |
| Neuroinflammation in neurodegenerative disorders: the roles of microglia and ast [PMID:33239064] | Kwon, Koh | Translational neurodegeneratio | 2021 | 0 |
| AIM2 in regulatory T cells restrains autoimmune diseases. [PMID:33505023] | Chou WC, Guo Z, Guo H | Nature | 2021 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.76 · 2026-04-26
active · Rounds: 3 · Score: 0.75 · 2026-04-26
active · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
active · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
Hypotheses and analyses mentioning gut microbiome dysbiosis in their description or question text
No additional research found