gene

STAM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

0Outgoing

2Incoming

0Experiments

0Debates

Summary

STAM2 gene encoding signal transducing adaptor molecule involved in endolysosomal pathway, ESCRT complex, and Parkinson's disease susceptibility

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🧬 Gene Info

Gene Symbol	STAM2
Function	is a key component of the ESCRT-0 complex that plays a critical role in endolysosomal trafficking and protein clearance.
Amino Acids	424 aa
Ensembl ID	ENSG00000084073
GeneCards	STAM2
Human Protein Atlas	STAM2
UIM (Ubiquitin-Interacting Motif)	Binds ubiquitin-tagged cargo proteins
SH3 Domain	Mediates protein-protein interactions with signaling molecules
MIT Domain	Interacts with ESCRT-III proteins for cargo sorting
Genetic Findings	Rare loss-of-function variants in STAM1/STAM2 increase PD risk
Transcriptomic Changes	STAM2 expression is altered in PD substantia nigra
Proteomic Evidence	STAM2 protein levels correlate with alpha-synuclein burden
Functional Validation	STAM2 deficiency leads to lysosomal dysfunction and alpha-synuclein accumulation[@stam2_lysosomal_2021]
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STAM2 Gene - Signal Transducing Adaptor Molecule 2

gene · 648 words

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Pathway Diagram

graph TD
    STAM2["STAM2"]
    neurodegeneration["neurodegeneration"]
    STAM2 -->|"implicated_in"| neurodegeneration
    style STAM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (2)

Source	Relation	Type	Str
genes-stam2	documents	wiki	1.00
genes-stam2	describes	wiki	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STAM2 in their description or question text

No additional research found