Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about gap junction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Blood-Brain Barrier Permeability | regulates | phenotype | 0.85 |
| degenerative stress | mediates | phenotype | 0.80 |
| optic neuropathy | implicated_in | disease | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astroglial Gap Junction Coordination via Connexin-43 Phospho | 0.720 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Gap Junction Hemichannel Modulation for Controlled Mitochond | 0.291 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
cell biology | 2026-04-12 | 2 hypotheses Top: 0.724
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cx43 knockdown effects on mitochondrial transfer | exploratory | osteoarthritis | 0.900 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Leukocyte gene expression analysis in COVID-19 patients | exploratory | COVID-19 | 0.900 | 0.00 | human leukocytes from COVID-19 | proposed | N/A |
| Confocal imaging of MSC-chondrocyte interactions during mitochondrial | exploratory | osteoarthritis | 0.850 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991] | Zhang Y, Kini SA, Mishkanian SA, Yarishk | Science | 2025 | 1 |
| GJA1-20k and Mitochondrial Dynamics. [PMID:35399255] | Shimura D, Shaw RM | Front Physiol | 2022 | 1 |
| Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944] | Li X, Zhao H, Tan X, Kostrzewa RM, Du G, | Glia | 2015 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] | Xiao F, Tan X, He A, Zhou Y, Xu K et al. | Autophagy | 2026 | 0 |
| The relationship between Connexin 43 (Cx43) and partner protein, human discs lar [PMID:41703342] | ["Scott H", "Dong L", "Stevenson A", "Ma | Cell and tissue research | 2026 | 0 |
| Thermal Adaptation Inhibits the Wnt Signaling Pathway Regulating Autophagy and I [PMID:41889212] | ["Song R", "Zhang Z", "Zhu S", "Fu K", " | Molecular reproduction and dev | 2026 | 0 |
| Identification and validation of ferroptosis-related genes for diabetic nephropa [PMID:41825713] | Duan H, Wang Y, Wang Q, Yan J, Fan X, Wu | European journal of pharmacolo | 2026 | 0 |
| Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505] | Chen S, Zhou X, Wang W, Zheng Y, Kang R, | International immunopharmacolo | 2026 | 0 |
| Reproductive tissue-derived stromal cells rescue fertility by coupling follicula [PMID:41888633] | ["Borutinskait\u0117 V", "Krastinait\u01 | Stem cells translational medic | 2026 | 0 |
| A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157] | ["Zhong R", "Yang H", "Li X", "Wang F", | Journal of inflammation resear | 2026 | 0 |
| Essential Role of CD63 in Maintaining Corneal Epithelial Identity in the Human L [PMID:41817143] | ["Sasamoto Y", "Suzuki K", "Sato S", "Le | Investigative ophthalmology & | 2026 | 0 |
| Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710] | Minogue PJ, Beyer EC, Berthoud VM | International journal of molec | 2026 | 0 |
| Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821] | ["Chi Q", "Xu H", "Li H", "Ma G", "Li X" | Journal of molecular histology | 2026 | 0 |
| SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010] | Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S | Phytomedicine : international | 2026 | 0 |
| Transcriptome and alternative splicing analyses uncover immune-centric pathogene [PMID:41911957] | ["Yan W", "Na L", "Tao G", "Jing L", "Yi | Gene | 2026 | 0 |
| Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013] | ["S\u00e1ez J", "Ocaranza F", "Prieto-Vi | Journal of neurochemistry | 2025 | 0 |
| Overlap in synaptic neurological condition susceptibility pathways and the neura [PMID:37807670] | ["Frederiksen S", "Wicki-Stordeur L", "S | Channels (Austin, Tex.) | 2023 | 0 |
| Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] | Persson RM, Tellnes K, Hoven H, Haaverst | Anaesthesia reports | 2022 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning gap junction in their description or question text
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