Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about early AD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| OPC pre-inflammatory state | associated_with | cell_type | 0.70 |
| sTREM2 | associated_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Real-time gamma-guided transcranial focused ultrasound targe | 0.827 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| X-Linked KDM6A Escapes X-Inactivation to Drive Female-Biased | 0.671 | Alzheimer disease | Sex-Specific Microglial States in Amyloi |
| APOE ε4-driven microglial lipid handling as proximal driver | 0.626 | neurodegeneration | Non-Neuronal Transcriptional Changes Pre |
| Cell-state stratification is required to resolve Non-Neurona | 0.612 | neurodegeneration | Non-Neuronal Transcriptional Changes Pre |
| Perturbation-first validation should precede therapeutic cla | 0.608 | neurodegeneration | Non-Neuronal Transcriptional Changes Pre |
| Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA- | 0.431 | molecular neurobiology | View |
| GrimAge Acceleration as a Cell-Type-Resolved CSF Biomarker P | 0.369 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 0 hypotheses
neurodegeneration | 2026-04-26 | 5 hypotheses Top: 0.712
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.559
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal | in_vivo | Alzheimer's disease | 0.744 | 0.48 | hAPP-J20 mice (n=10/group x 3 | abandoned | $110,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Association of CSF α-synuclein seed amplification assay positivity with disease [PMID:39428831] | Tosun, Hausle, Thropp, Concha-Marambio, | Alzheimer's & dementia : the j | 2025 | 0 |
| CSF markers of vascular injury correlate with tau and cognitive decline in early [PMID:41319164] | Miners, Roy, Love | Alzheimer's & dementia : the j | 2025 | 0 |
| Association of CSF α-synuclein seed amplification assay positivity with disease [PMID:39428831] | Unknown | Alzheimer's & dementia : the j | 2025 | 0 |
| CSF markers of vascular injury correlate with tau and cognitive decline in early [PMID:41319164] | Unknown | Alzheimer's & dementia : the j | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Sex Differences in Alzheimer's Disease. [PMID:37030962] | Aggarwal, Mielke | Neurologic clinics | 2023 | 0 |
| Sex Differences in Alzheimer's Disease. [PMID:37030962] | Unknown | Neurologic clinics | 2023 | 0 |
| DunedinPACE, a DNA methylation biomarker of the pace of aging. [PMID:35029144] | Belsky DW, Caspi A, Corcoran DL | Elife | 2022 | 0 |
| Epigenetic GrimAge acceleration and cognitive impairment in bipolar disorder. [PMID:35810614] | Lima CNC, Suchting R, Scaini G | Eur Neuropsychopharmacol | 2022 | 0 |
| Epigenetic clock: A promising biomarker and practical tool in aging. [PMID:36206857] | Duan R, Fu Q, Sun Y | Ageing Res Rev | 2022 | 0 |
| DNA methylation GrimAge version 2. [PMID:36516495] | Lu AT, Binder AM, Zhang J | Aging (Albany NY) | 2022 | 0 |
| CSF tau microtubule binding region identifies tau tangle and clinical stages of [PMID:33283854] | Horie K, Barthélemy NR, Sato C, Bateman | Brain : a journal of neurology | 2021 | 0 |
| CSF tau microtubule binding region identifies tau tangle and clinical stages of [PMID:33283854] | Horie K, Barthélemy NR, Sato C, Bateman | Brain : a journal of neurology | 2021 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Impaired glymphatic function and clearance of tau in an Alzheimer's disease mode [PMID:32705145] | Harrison IF, Ismail O, Machhada A, Colga | Brain : a journal of neurology | 2020 | 0 |
| Impaired glymphatic function and clearance of tau in an Alzheimer's disease mode [PMID:32705145] | Harrison IF, Ismail O, Machhada A, Colga | Brain : a journal of neurology | 2020 | 0 |
| DNA methylation GrimAge strongly predicts lifespan and healthspan. [PMID:30669119] | Lu AT, Quach A, Wilson JG | Aging (Albany NY) | 2019 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 6 · Score: 0.83 · 2026-04-27
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 7 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning early AD in their description or question text
Score: 0.431 · molecular neurobiology · 2026-04-21
## Mechanistic Overview Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-9969 Exosome Therapy Precision in Ea
Score: 0.369 · unknown disease · 2026-04-25
Concise Statement: GrimAge-derived epigenetic age acceleration, when deconvoluted for neuronal vs. glial cell-type prop