Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about disease severity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Motor Fluctuations | risk_factor_for | phenotype | 0.90 |
| Levodopa-Induced Dyskinesia | risk_factor_for | phenotype | 0.90 |
| Levodopa-induced dyskinesia | associated_with | phenotype | 0.80 |
| Gold Coast Consensus Criteria | associated_with | biomarker | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 29614695 | decreases disease severity in a dose-dependent manner | paper | 0.90 |
| 29614695 | is predictive of | paper | 0.90 |
| NBR1 | correlates_with | protein | 0.90 |
| TARDBP | correlates_with | protein | 0.90 |
| MAPT | correlates_with | protein | 0.90 |
| Extracellular Vesicle TDP-43 | correlates_with | biomarker | 0.88 |
| lnc-HIBADH-4 | correlates_with | biomarker | 0.85 |
| Tau Aggregates | correlates_with | biomarker | 0.85 |
| Mitochondrial Proteins Downregulation | correlates_with | phenotype | 0.85 |
| IL-6 | markers | gene | 0.80 |
| Autophagy-Related Protein Expression | correlates_with | biomarker | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning disease severity in their description or question text
No additional research found