entity

alectinib

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about alectinib: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

8Hypotheses

1Analyses

2Outgoing

1Incoming

0Experiments

2Debates

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Outgoing (2)

Target	Relation	Type	Str
C1q non-specific precipitation	causes	mechanism	0.70
human serum albumin	binds	protein	0.70

Incoming (1)

Source	Relation	Type	Str
C1Q	binds	gene	0.90

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Combined NAMPT-Alectinib Targeting of SASP-Complement Cascad	0.549	neuroinflammation	How does Alectinib, a kinase inhibitor,
Alectinib-C1q Complex Hijacks TREM2's Synaptic Protective Bi	0.500	neuroinflammation	How does Alectinib, a kinase inhibitor,
C1q-Alectinib Complexation Disrupts Tight Junction Integrity	0.445	molecular biology	Does Alectinib truly bind C1q directly w
C1q-Alectinib Complexation Enhances CNS Penetration via Micr	0.415	molecular biology	Does Alectinib truly bind C1q directly w
Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri	0.406	molecular biology	Does Alectinib truly bind C1q directly w

C1q-Alectinib Complexation Facilitates Brain Penetration via	0.161	molecular biology	Does Alectinib truly bind C1q directly w
Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rat	0.122	molecular biology	Does Alectinib truly bind C1q directly w
Alectinib's Putative C1q Binding Derives from Hydrophobic Ag	0.105	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PAK [PMID:41824279]	["Razak A", "Mahipal A", "Diamond JR", "	Target Oncol	2026	0
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic st [PMID:25709099]	["Sampath D", "Zabka TS", "Misner DL", "	Pharmacol Ther	2015	0

Debates (2)

Multi-agent debates referencing this entity

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning alectinib in their description or question text

C1q-Alectinib Complexation Facilitates Brain Penetration via Receptor-Mediated T

Score: 0.161 · molecular biology · 2026-04-18

## Mechanistic Overview C1q-Alectinib Complexation Facilitates Brain Penetration via Receptor-Mediated Transcytosis star

Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating

Score: 0.122 · molecular biology · 2026-04-18

## Mechanistic Overview Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating C1q starts from

Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Tha

Score: 0.105 · molecular biology · 2026-04-18

## Mechanistic Overview Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Than Direct Protein