Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about acetate: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| histone acetylation | promotes | process | 0.89 |
| Gut-Brain Communication | involved_in | pathway | 0.85 |
| Blood-Brain Barrier Integrity | protects_against | phenotype | 0.85 |
| Gut-Brain Axis | involved_in | pathway | 0.85 |
| HDAC3 | interacts_with | gene | 0.85 |
| Pancreatic Acinar Cell Damage | protects_against | phenotype | 0.85 |
| HDAC3 | activates | gene | 0.80 |
| NF-κB pathway | inhibits | pathway | 0.80 |
| pancreatic acinar cell necrosis | inhibits | process | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 24781306 | crosses | paper | 0.90 |
| 24781306 | changes expression profiles of | paper | 0.90 |
| riboflavin | upregulates | compound | 0.80 |
| HDAC3 | regulates | gene | 0.75 |
| 24781306 | has a direct role in | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Propionate may outperform acetate or butyrate at physiologic | 0.440 | neurodegeneration | Do physiological concentrations of SCFAs |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning acetate in their description or question text
No additional research found