gene

XRCC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XRCC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

5Outgoing

1Incoming

0Experiments

0Debates

Summary

XRCC6 Gene

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🧬 Gene Info

Gene Symbol	XRCC6
Full Name	X-Ray Repair Cross-Complementing 6 (Ku70)
Chromosome	22q13.2
Function	The XRCC6 gene encodes X-Ray Repair Cross-Complementing 6 (Ku70), involved in DNA repair and genomic stability
Pathways	Nf-Κb
UniProt ID	XRCC6
NCBI Gene ID	7520
Ensembl ID	ENSG00000105928
OMIM	194361
GeneCards	XRCC6
Human Protein Atlas	XRCC6
DNA repair	Critical for maintaining genomic integrity
Cell cycle regulation	Coordinates DNA repair with cell cycle progression
[Apoptosis](/entities/apoptosis)	Modulates apoptotic response to DNA damage
Neuronal survival	Essential for long-term neuronal survival
Associated Diseases	neurodegeneration
Interactions	App, HERC5, RNA, UBIQUITIN
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

XRCC6 Gene

gene · 647 words

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Pathway Diagram

flowchart TD
    XRCC6(["XRCC6"])
    SOX2["SOX2"]
    Cancer["Cancer"]
    HERC5(["HERC5"])
    UBIQUITIN(["UBIQUITIN"])
    Nf__b["Nf-Kappab"]
    App(["App"])
    RNA(["RNA"])
    neurodegeneration["neurodegeneration"]

    SOX2 -->|"interacts with"| XRCC6
    XRCC6 -->|"activates"| Cancer
    XRCC6 -->|"activates"| HERC5
    XRCC6 -->|"activates"| UBIQUITIN
    XRCC6 -->|"activates"| Nf__b
    XRCC6 -->|"activates"| App
    RNA -->|"activates"| XRCC6
    XRCC6 -->|"implicated in"| neurodegeneration

    style XRCC6 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
HERC5	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
App	activates	protein	0.60

Incoming (1)

Source	Relation	Type	Str
RNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XRCC6 in their description or question text

No additional research found