WRN

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolWRN
NameWRN RecQ like helicase
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localizatio

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