Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WHITE_MATTER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice | validation | Alzheimer's disease | 0.950 | 0.00 | APP/PS1 transgenic mice (8 mon | proposed | N/A |
| SIRPα modulation in mouse models of Alzheimer's disease | validation | Alzheimer's disease | 0.900 | 0.00 | mouse models of Alzheimer's di | proposed | N/A |
| CXCL10 biomarker analysis for CPSP prediction | clinical | chronic postsurgical pain | 0.900 | 0.00 | human patients undergoing thor | proposed | N/A |
| PDGFRA and C-MYC protein validation in ovarian cancer tissues | exploratory | Ovarian cancer | 0.850 | 0.00 | Human ovarian cancer tissues | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| CD2AP expression and cognitive decline in AD patients | exploratory | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177] | Lin B, Zhou J, Geng D, Chai S, Zhang X e | Cell Death Differ | 2026 | 0 |
| Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603] | Ye L, Zhao T, Tian H, Li R, Li Z et al. | Sci China Life Sci | 2026 | 0 |
| METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934] | Sun Y, Ren Z, Ge J, Zhang W, Shao F et a | Biochim Biophys Acta Mol Basis | 2026 | 0 |
| Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107] | Lan T, Shang D, Lin L, Wang H, Zou J et | Autophagy | 2026 | 0 |
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805] | Nie W, Wang M, Cheng M, Ren Z, Liu G et | J Ethnopharmacol | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095] | Peng M, Shu D, Chen Z, Yang Z, Zhang M e | J Neuroinflammation | 2026 | 0 |
| Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814] | Zhang X, Xue J, Zhao C, Zeng C, Zhong J | J Clin Invest | 2026 | 0 |
| Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144] | Daood R, Naffaa ME, Azrilin O, Hassan F, | Clin Rheumatol | 2026 | 0 |
| Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] | Yu D, Kang J, Jiang W, Zhang C, Zhao X e | Neuropharmacology | 2026 | 0 |
| Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] | Li Z, Tan B, Dong K, Yu X, Zhang SW et a | Biochem Pharmacol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] | Main BS, Villapol S, Buenaventura RG, Ha | Brain Behav Immun | 2026 | 0 |
| Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] | Bruna-Jara B, More J, Lobos P, Ponce DP, | Scientific reports | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |
| Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958] | Wu W, Cheng Z, Shi P, Gao H, Chen X et a | Bioact Mater | 2026 | 0 |
| Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958] | Kim ST, Bass AR | Arthritis Rheumatol | 2026 | 0 |
| Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188] | Zangas P, Georgakis MK | Curr Atheroscler Rep | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning WHITE_MATTER in their description or question text
Score: 0.651 · neurodegeneration · 2026-04-02
## Mechanistic Overview Oligodendrocyte White Matter Vulnerability starts from the claim that modulating MOG within the
Score: 0.649 · neurodegeneration · 2026-04-17
**Molecular Mechanism and Rationale** The TREM2-mediated oligodendrocyte-microglia metabolic coupling pathway represent
Score: 0.644 · neurodegeneration · 2026-04-04
## Mechanistic Overview White Matter Immune Checkpoint Restoration starts from the claim that modulating CXCL10 within t
Score: 0.600 · neurodegeneration · 2026-04-21
## **Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) signaling pathway
Score: 0.599 · Alzheimer's disease · 2026-04-04
## Mechanistic Overview OPC differentiation blockade contributes to white matter degeneration in early-stage AD starts f
Score: 0.587 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The TREM2-mediated oligodendrocyte-microglia signaling axis represents a sophisti