gene

VPS45

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS45: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for VPS45 — Vacuolar Protein Sorting 45 Homolog

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🧬 Gene Info

Gene Symbol	VPS45
Full Name	Vacuolar Protein Sorting 45 Homolog
Chromosome	1q21.2
Function	is a critical regulator of intracellular membrane trafficking, particularly within the endosomal and secretory pathways.
Primary Expression	neurons and glial cells, including astrocytes and microglia
Amino Acids	524 aa
Ensembl ID	ENSG00000136631
GeneCards	VPS45
Human Protein Atlas	VPS45
SNARE Proteins	VPS45 binds to syntaxin proteins (particularly Syntaxin 16 and Syntaxin 6) to regulate SNARE complex assembly
Rab GTPases	Works with Rab5 and Rab7 in early and late endosome function
HOPS Complex	Collaborates with the homotypic fusion and vacuole protein sorting (HOPS) complex for late endosome-lysosome fusion
ESCRT Machinery	Functions in endosomal sorting complex required for transport (ESCRT) pathways
Amyloid Processing	VPS45 regulates trafficking of the amyloid precursor protein (APP) and β-secretase (BACE1), affecting amyloid-β production
Autophagy Impairment	Defective VPS45 function leads to impaired autophagic clearance of protein aggregates, including amyloid plaques and neurofibrillary tangles
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VPS45 — Vacuolar Protein Sorting 45 Homolog

gene · 1224 words

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Pathway Diagram

graph TD
    VPS45["VPS45"]
    neurodegeneration["neurodegeneration"]
    VPS45 -->|"implicated_in"| neurodegeneration
    style VPS45 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning VPS45 in their description or question text

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