Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UNC5D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | UNC5D |
| Full Name | UNC-5 Netrin Receptor D |
| Chromosome | 8p23.1 |
| Protein Type | Receptor |
| Function | is a type I transmembrane receptor composed of multiple functional domains that mediate ligand binding, downstream signaling, and interactions with adaptor proteins. |
| Primary Expression | Brain (cortex, cerebellum), embryonic |
| UniProt ID | [Q6ZNG7](https://www.uniprot.org/uniprot/Q6ZNG7) |
| GeneCards | UNC5D |
| Human Protein Atlas | UNC5D |
| Death domain (DD) | Triggers caspase-dependent apoptosis when the receptor is unbound to ligand |
| ZU-5 domain | Mediates protein-protein interactions with downstream effectors |
| PXXP motifs | Bind SH3 domain-containing adaptor proteins including TRAF6 and NCK |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UNC5D["UNC5D"]
style UNC5D fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
DCC["DCC"]
UNC5A["UNC5A"]
UNC5B["UNC5B"]
UNC5C["UNC5C"]
neurodegeneration["neurodegeneration"]
DCC -->|"regulates"| UNC5D
UNC5A -->|"regulates"| UNC5D
UNC5B -->|"regulates"| UNC5D
UNC5C -->|"regulates"| UNC5D
UNC5D -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class DCC gene
class UNC5A gene
class UNC5B gene
class UNC5C gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UNC5D in their description or question text
No additional research found