Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TYDP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TYDP1 encodes TDP1, a DNA repair enzyme that removes topoisomerase I-DNA complexes. Mutations cause neurodegeneration with parkinsonism; implicated in PD pathophysiology.
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| Gene Symbol | TYDP1 |
| Full Name | Tyrosyl-DNA Phosphodiesterase 1 |
| Chromosome | 14q32.12 |
| Protein Type | Enzyme |
| Function | is a gene located on chromosome 14q32. |
| Molecular Weight | 68.5 kDa |
| Amino Acids | 608 aa |
| Exons | 14 |
| GeneCards | TYDP1 |
| Human Protein Atlas | TYDP1 |
| N-terminal PINc domain (residues 1-500) | The catalytic nuclease domain with a beta-helix barrel structure containing four conserved acidic residues (D275, E277, H394, H423) that coordinate two metal ions (Mg2+ or Mn2+) for catalysis. |
| C-terminal region (residues 500-608) | Regulatory region with proposed nuclear localization signal and protein-protein interaction motifs. |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TYDP1["TYDP1"]
neurodegeneration["neurodegeneration"]
TYDP1 -->|"implicated_in"| neurodegeneration
style TYDP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning TYDP1 in their description or question text
No additional research found