gene

TUBA1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

TUBA1A encodes the major neuronal alpha-tubulin isoform, critical for microtubule assembly, axonal transport, and neuronal polarity. Mutations cause lissencephaly and microtubule defects in AD/PD.

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🧬 Gene Info

Gene Symbol	TUBA1A
Full Name	Tubulin Alpha 1A
Chromosome	12q13.12
Protein Type	Gene
Function	is a gene located on chromosome 12q13.
Primary Expression	neurons of the developing and adult central nervous system
Molecular Weight	50 kDa
Amino Acids	450 aa
Exons	5
GeneCards	TUBA1A
Human Protein Atlas	TUBA1A
N-terminal GTP-binding domain	Contains the exchangeable GTP site (N-site) that binds GTP, which is hydrolyzed to GDP during microtubule polymerization. This domain is critical for tubulin dimer formation and microtubule dynamics.
Intermediate domain	Variable region that determines isoform-specific properties and is the site of post-translational modifications.
C-terminal tail	Contains the binding site for microtubule-associated proteins (MAPs), motor proteins (kinesins and dynein), and the site of polyglutamylation and polyglycylation modifications.
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TUBA1A — Tubulin Alpha 1A

gene · 2043 words

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TUBA1A Protein

protein · 1299 words

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Pathway Diagram

flowchart TD
    N0["TUBA1A"]
    N1["Bpmc"]
    N1 -->|"downregulates"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
Bpmc	downregulates	compound	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUBA1A in their description or question text

No additional research found