Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM55: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | Tripartite Motif Containing 55 |
| Chromosome | 8q24.13 |
| Protein Type | Ligase |
| Function | is a muscle-specific E3 ubiquitin ligase that plays critical roles in muscle protein degradation, sarcomere maintenance, and cellular protein quality control[@centner2001]. |
| Primary Expression | skeletal and cardiac muscle, where it functions as an E3 ubiquitin ligase involved in: |
| Gene Type | Protein Coding |
| UniProt ID | Q9C0B1 |
| NCBI Gene ID | 80316 |
| Ensembl ID | ENSG00000138182 |
| OMIM | 608598 |
| Sarcomere maintenance | Targets structural proteins for ubiquitination and degradation |
| Muscle protein turnover | Regulates degradation of contractile proteins |
| Troponin degradation | Interacts with troponin complex components |
| Myosin binding | Associates with myosin binding proteins |
| High expression | Skeletal muscle, cardiac muscle |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM55["TRIM55"]
neurodegeneration["neurodegeneration"]
TRIM55 -->|"implicated_in"| neurodegeneration
style TRIM55 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRIM55 in their description or question text
No additional research found