gene

TREML2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREML2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

1Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for TREML2 — Triggering Receptor Expressed on Myeloid Cells-Like 2

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🧬 Gene Info

Gene Symbol	TREML2
Full Name	Triggering Receptor Expressed on Myeloid Cells-Like 2
Chromosome	6p21.1.
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	patterns [6]. These database references provide foundational information for researchers investigating TREML2 function a
Ensembl ID	ENSG00000162009
GeneCards	TREML2
Human Protein Atlas	TREML2
Associated Diseases	neurodegeneration
SciDEX Hypotheses	Astrocytic TREM2-Like Receptor Modulation of Synap
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TREML2 — Triggering Receptor Expressed on Myeloid Cells-Like 2

gene · 1771 words

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TREML2 Protein (TREM-like transcript 2)

protein · 1124 words

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Pathway Diagram

graph TD
    TREML2["TREML2"]
    neurodegeneration["neurodegeneration"]
    TREML2 -->|"implicated_in"| neurodegeneration
    style TREML2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocytic TREM2-Like Receptor Modulation of Synaptic Streng	0.380	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer' [PMID:41929946]	["Behroozi Zahra", "Askarpour Hedyeh", "	Journal of Alzheimer's disease	2026
Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in e [PMID:32991925]	Unknown	Behav Brain Res	2021
Disease-modifying treatment with I(2) imidazoline receptor ligand LSL60101 in an [PMID:33817786]	Unknown	Br J Pharmacol	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TREML2 in their description or question text

No additional research found