| Gene Symbol | TREML2 |
| Full Name | TREML2 — Triggering Receptor Expressed on Myeloid Cells-Like 2 |
| Aliases | Triggering Receptor Expressed on Myeloid Cells-Like 2 |
| Chromosome | 6p21.1. |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Ensembl ID | ENSG00000162009 |
| GeneCards | TREML2 |
| Human Protein Atlas | TREML2 |
| Extracellular Ig-like domain | The N-terminal portion contains an immunoglobulin V-type (IgV) domain that mediates ligand binding. This domain shares approximately 40% sequence similarity with TREM2's IgV domain. |
| Transmembrane domain | A short hydrophobic transmembrane helix anchors the protein in the cell membrane |
| Cytoplasmic tail | Contains a short cytoplasmic domain with potential signaling motifs |
| Lipids | Various lipid species including phosphatidylserine and oxidized lipids |
| Apolipoproteins | ApoE and other apolipoproteins |
| Bacterial products | Certain bacterial cell wall components |
| Associated Diseases | neurodegeneration |
| SciDEX Hypotheses | Astrocytic TREM2-Like Receptor Modulation of Synap |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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