Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2 variants: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Trem2 Surface Expression | downregulates | phenotype | 0.92 |
| Trem2 Signaling | modulates | pathway | 0.90 |
| Alzheimer's disease | risk_factor_for | disease | 0.90 |
| Ligand Binding | causes | mechanism | 0.88 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 31235932 | associated with increased risk for | paper | 0.90 |
| 41648425 | established as genetic risk factors for | paper | 0.90 |
| 41648425 | have been established as genetic risk factors for | paper | 0.90 |
| 39032157 | increase AD risk by disrupting | paper | 0.90 |
| 31649511 | increase risk of | paper | 0.90 |
| APOE ε4 | modulates | gene | 0.60 |
| 39032157 | may increase AD risk by disrupting | paper | 0.60 |
| 39032157 | may increase | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning TREM2 variants in their description or question text
No additional research found