Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2 and C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SOX10 and DLX1/2 | co_associated_with | gene | 0.40 |
| SYN1, SLC1A2, and CX3CR1 | co_associated_with | gene | 0.40 |
| EIF2AK3 (PERK) and EIF2B complex | co_associated_with | gene | 0.40 |
| APOE | co_associated_with | gene | 0.40 |
| BMP4 and BMPR1A | co_associated_with | gene | 0.40 |
| PARP1 and XRCC1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial TREM2-Complement Axis Modulation | 0.726 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.726
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Microglia-neuron crosstalk in Alzheimer's disease: an exploration of molecular m [PMID:40651657] | Unknown | Neuroscience | 2025 | 0 |
| Age-related inflammatory changes and perineuronal net dynamics: implications for [PMID:41254697] | ["Zachary A Colon", "Shannon C Chan", "K | Journal of neuroinflammation | 2025 | 0 |
| Cerebrospinal fluid β2-microglobulin promotes the tau pathology through mi [PMID:39748415] | ["Zehu Sheng", "Lanyang Wang", "Ming Che | Alzheimer's research & the | 2025 | 0 |
| Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease. [PMID:39272998] | Unknown | Cells | 2024 | 0 |
| The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pa [PMID:38255891] | Unknown | International journal of molec | 2024 | 0 |
| The emerging role of disease-associated microglia in Parkinson's disease. [PMID:39564189] | Unknown | Frontiers in cellular neurosci | 2024 | 0 |
| Neuroinflammation, its Role in Alzheimer's Disease and Therapeutic Strategie. [PMID:37874089] | Unknown | The journal of prevention of A | 2023 | 0 |
| Microglia in Alzheimer's Disease: An Unprecedented Opportunity as Prospective Dr [PMID:35149973] | Unknown | Molecular neurobiology | 2022 | 0 |
| Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclini [PMID:36180898] | Faridar A, Vasquez M, Thome AD, Yin Z, X | Acta neuropathologica communic | 2022 | 0 |
| Immune Signaling in Neurodegeneration. [PMID:30995509] | Unknown | Immunity | 2019 | 0 |
| Intersection of pathological tau and microglia at the synapse. [PMID:31277708] | ["Vogels Thomas", "Murgoci Adriana-Natal | Acta neuropathologica communic | 2019 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning TREM2 and C3 in their description or question text
No additional research found