Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARP1 and XRCC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| SOX10 and DLX1/2 | co_associated_with | gene | 0.40 |
| SYN1, SLC1A2, and CX3CR1 | co_associated_with | gene | 0.40 |
| TREM2 and C3 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | co_associated_with | gene | 0.40 |
| BMP4 and BMPR1A | co_associated_with | gene | 0.40 |
| EIF2AK3 (PERK) and EIF2B complex | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Oligodendrocyte DNA Repair Enhancement Therapy | 0.665 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.726
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544] | Köcher S, Elsesy ME, Moustafa A, Mohamma | J Clin Invest | 2026 | 0 |
| Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453] | Shao B, Yin H, Zhang S, He S, Lu H et al | Cancer Genet | 2026 | 0 |
| Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852] | Liu J, Gonzalez-Hunt CP, Richbourg T, Ba | bioRxiv : the preprint server | 2026 | 0 |
| PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038] | Dumoulin I, Lee BJ, Zhang C, Lin X, Wang | bioRxiv | 2026 | 0 |
| Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005] | Wan Z, Li X, Wang Y, Miao S, Chen Z et a | Insects | 2026 | 0 |
| Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367] | Dauben H, Mihaljević M, Kolvenbach A, Pa | Nat Commun | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PARP1 and XRCC1 in their description or question text
No additional research found