protein

TRA2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRA2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TRA2B (Transformer-2 beta) is an RNA-binding protein essential for alternative splicing regulation in neurons. This page covers its structure, function in the nervous system, and role in ALS, Alzheimer's, and Parkinson's diseases.

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🔬 Protein Info

Gene Symbol	TRA2B
Full Name	Transformer 2 Beta Homolog
Aliases	Transformer-2 beta
Chromosome	3q27.2
Function	TRA2B functions as a sequence-specific RNA-binding protein that promotes exon inclusion during pre-mRNA splicing.
Molecular Weight	33 kDa
Amino Acids	288 aa
UniProt ID	[Q13595](https://www.uniprot.org/uniprot/Q13595)
Ensembl ID	ENSG00000161940
OMIM	605200
GeneCards	TRA2B
Human Protein Atlas	TRA2B
Exon Recognition	TRA2B binds to exonic splicing enhancers (ESEs), helping the spliceosome identify correct splice sites
Alternative Splicing Regulation	Controls inclusion/exclusion of alternatively spliced exons in neuronal transcripts
Neuronal Transcriptome Diversity	Generates splice variants essential for neuronal function
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TRA2B — Transformer 2 Beta Homolog

gene · 916 words

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TRA2B Protein - Transformer-2 Beta

protein · 4438 words

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Pathway Diagram

graph TD
    TRA2B["TRA2B"]
    neurodegeneration["neurodegeneration"]
    TRA2B -->|"implicated_in"| neurodegeneration
    style TRA2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TRA2B in their description or question text

No additional research found