compound

TMAO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMAO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

1Analyses

3Outgoing

0Incoming

0Experiments

1Debates

No summary available yet.

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💊 Drug Info

Name	TMAO
Key Genes/Proteins	AQP4, STAT3

Pathway Diagram

graph TD
    TMAO["TMAO"] -->|"activates"| NFKB["NFKB"]
    style NFKB fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TMAO["TMAO"] -->|"regulates"| TNF["TNF"]
    style TNF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TMAO["TMAO"] -->|"regulates"| IL6["IL6"]
    style IL6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TMAO["TMAO"] -->|"regulates"| IL1B["IL1B"]
    style IL1B fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TMAO["TMAO"] -->|"regulates"| ROS["ROS"]
    style ROS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TMAO["TMAO"] -->|"associated"| ASTROCYTES["ASTROCYTES"]
    style ASTROCYTES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TMAO["TMAO"] -->|"involved in"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Shexiang_Baoxin_Pill["Shexiang Baoxin Pill"] -->|"regulates"| TMAO["TMAO"]
    style Shexiang_Baoxin_Pill fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Bile_Acid_Synthesis["Bile Acid Synthesis"] -->|"regulates"| TMAO["TMAO"]
    style Bile_Acid_Synthesis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style TMAO fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (3)

Target	Relation	Type	Str
endothelial cell apoptosis	promotes	process	0.85
STAT3	activates	gene	0.80
AQP4	downregulates	protein	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.778

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synucle

closed · Rounds: 4 · Score: 0.84 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TMAO in their description or question text

No additional research found