entity

TDP-43_pathology

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43_pathology: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

6Hypotheses

6Analyses

0Outgoing

1Incoming

0Experiments

7Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
MMP9	generates	gene	0.50

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD	0.720	neurodegeneration	Test Hypothesis Fixtures
Glial Neuroinflammatory Amplification by TDP-43 Pathology	0.680	neurodegeneration	What mechanisms underlie TDP-43's contri
TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Ca	0.678	neurodegeneration	What mechanisms underlie neuronal resist
Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology	0.460	neuroinflammation	How does chronic cGAS/STING activation d
DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed	0.430	neurodegeneration	How does APOE4 mechanistically increase

TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signat	0.387	-	Epigenetic clocks as biomarkers for Alzh

Mentioning Analyses (6)

Scientific analyses that reference this entity

What are the mechanisms by which microglial senescence contributes to ALS pathol

neurodegeneration | 2026-04-26 | 10 hypotheses Top: 0.799

What mechanisms underlie TDP-43's contribution to cognitive impairment severity

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.680

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.693

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 3 hypotheses Top: 0.595

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.580

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of [PMID:40157356]	Rummens Jens; Khalil Bilal; Yıld&#	Neuron	2025
TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of [PMID:40157356]	["Rummens Jens", "Khalil Bilal", "Y\u013	Neuron	2025
The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not [PMID:38079474]	Zibold, Lessard, Picard, da Silva, Zador	Brain : a journal of neurology	2024
TDP-43 nuclear condensation and neurodegenerative proteinopathies. [PMID:39327159]	Vassallu, Igaz	Trends in neurosciences	2024
TDP-43 nuclear condensation and neurodegenerative proteinopathies. [PMID:39327159]	Unknown	Trends in neurosciences	2024
The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not [PMID:38079474]	Unknown	Brain : a journal of neurology	2024
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and ag [PMID:35112738]	Gruijs da Silva LA, Simonetti F, Hutten	The EMBO journal	2022
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and ag [PMID:35112738]	Gruijs da Silva LA, Simonetti F, Hutten	The EMBO journal	2022
FUS and TDP-43 Phases in Health and Disease. [PMID:33446423]	["Portz Bede", "Lee Bo Lim", "Shorter Ja	Trends in biochemical sciences	2021
FUS and TDP-43 Phases in Health and Disease. [PMID:33446423]	["Portz Bede", "Lee Bo Lim", "Shorter Ja	Trends in biochemical sciences	2021

Debates (7)

Multi-agent debates referencing this entity

Investigate how microglial senescence drives ALS progression through inflammatio

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the mechanisms by which microglial senescence contributes to ALS pathol

closed · Rounds: 6 · Score: 0.75 · 2026-04-26

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The abstract identifies APOE4 association with increased TDP-43 pathology but th

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

closed · Rounds: 4 · Score: 0.77 · 2026-04-21

AD patients with TDP-43 pathology show worse cognitive impairment, but how TDP-4

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TDP-43_pathology in their description or question text

TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signature Divergence" Dete

Score: 0.387 · unknown disease · 2026-04-25

Concise Statement: TDP-43 proteinopathy (as seen in LATE — Limbic-predominant Age-related TDP-43 Encephalopathy) genera

TDP-43_pathology

Understanding Entity Pages

Outgoing (0)

Incoming (1)

Targeting Hypotheses (6)

Mentioning Analyses (6)

What are the mechanisms by which microglial senescence contributes to ALS pathol

What mechanisms underlie TDP-43's contribution to cognitive impairment severity

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Experiments (0)

Related Papers (10)

Debates (7)

Investigate how microglial senescence drives ALS progression through inflammatio

What are the mechanisms by which microglial senescence contributes to ALS pathol

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

The abstract identifies APOE4 association with increased TDP-43 pathology but th

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

AD patients with TDP-43 pathology show worse cognitive impairment, but how TDP-4

Related Research

TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signature Divergence" Dete