gene

TBL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TBL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for TBL2 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TBL2
Chromosome	7q11.23
Function	encodes a WD40 repeat-containing protein that plays important roles in cellular signal transduction, protein quality control, and transcriptional regulation.
Primary Expression	Purkinje cells and granule cells
Amino Acids	60 aa
GeneCards	TBL2
Human Protein Atlas	TBL2
N-terminal domain	Involved in protein targeting and localization
WD40 repeat region	Forms the structural core for protein-protein interactions
C-terminal region	Contains regulatory elements and post-translational modification sites
Substantia nigra	Present in dopaminergic neurons of the pars compacta
Cerebellum	Expressed in Purkinje cells and granule cells
Hypothalamus	Moderate expression in various nuclei
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TBL2 Gene

gene · 1000 words

→

Pathway Diagram

graph TD
    TBL2["TBL2"]
    neurodegeneration["neurodegeneration"]
    TBL2 -->|"implicated_in"| neurodegeneration
    style TBL2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TBL2 in their description or question text

No additional research found