Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sirtuin-3 / mitochondrial deacetylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SIRT3 | participates_in | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration | 0.701 | neurodegeneration | Epigenetic reprogramming in aging neuron |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Exercise-BDNF-Mitophagy Biomarker Study in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Lifestyle Intervention Mechanisms in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $430,000 |
| MLCS Quantification in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Sirtuin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Sirtuin Pathway Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Thera [PMID:40922457] | ["Eroglu E", "Harmanci N"] | Basic & clinical pharmacology | 2025 | 0 |
| Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic [PMID:40634825] | Wei P, Zhang X, Yan C, Sun S, Chen Z, Li | Biogerontology | 2025 | 0 |
| Bridging gap in the treatment of Alzheimer's disease via postbiotics: Current pr [PMID:39952328] | ["Bashir B", "Gulati M", "Vishwas S", "G | Ageing research reviews | 2025 | 0 |
| Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein [PMID:38266638] | Wang C, Chen Q, Chen S, Fan L, Gan Z, Zh | Molecular cell | 2024 | 0 |
| SIRT3-Mediated Deacetylation of SDHA Rescues Mitochondrial Bioenergetics Contrib [PMID:38087172] | ["Shen Y", "Wang X", "Nan N", "Fu X", "Z | Molecular neurobiology | 2024 | 0 |
| SIRT3: A potential therapeutic target for liver fibrosis. [PMID:38561088] | ["Ning Y", "Dou X", "Wang Z", "Shi K", " | Pharmacology & therapeutics | 2024 | 0 |
| Sirtuin family in autoimmune diseases. [PMID:37483618] | Tao Z, Jin Z, Wu J, Cai G, Yu X | Frontiers in immunology | 2023 | 0 |
| Mitochondrial sirtuins, metabolism, and aging. [PMID:34856390] | Ji Z, Liu GH, Qu J | Journal of genetics and genomi | 2022 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Curr Neuropharmacol | 2022 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Current neuropharmacology | 2022 | 0 |
| FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic [PMID:36134579] | Jin L, Geng L, Ying L, Shu L, Ye K, Yang | Circulation | 2022 | 0 |
| SIRT3 as a potential therapeutic target for heart failure. [PMID:33508434] | ["Chen J", "Chen S", "Zhang B", "Liu J"] | Pharmacological research | 2021 | 0 |
| Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disea [PMID:33444675] | Govindarajulu M, Ramesh S, Neel L | Neurochem Int | 2021 | 0 |
| Sirtuin3 in Neurological Disorders. [PMID:33290206] | Sherin F, Gomathy S, Antony S | Current drug research reviews | 2021 | 0 |
| Mitochondrial SIRT3 and neurodegenerative brain disorders. [PMID:29129747] | Anamika, Khanna A, Acharjee P, Acharjee | Journal of chemical neuroanato | 2019 | 0 |
| Editing the Central Nervous System Through CRISPR/Cas9 Systems. [PMID:31191241] | ["Cota-Coronado A", "D\u00edaz-Mart\u00e | Frontiers in molecular neurosc | 2019 | 0 |
| Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurode [PMID:24046746] | ["Kincaid B", "Bossy-Wetzel E"] | Frontiers in aging neuroscienc | 2013 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
Hypotheses and analyses mentioning Sirtuin-3 / mitochondrial deacetylation in their description or question text
No additional research found