gene

SURF6

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SURF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SURF6 — SURF6 Homolog

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🧬 Gene Info

Gene Symbol	SURF6
Full Name	Ribosome Biogenesis Factor
Aliases	SURF6 Homolog
Function	Its primary functions include
Ensembl ID	ENSG00000148229
GeneCards	SURF6
Human Protein Atlas	SURF6
SURF4	Co-assembles in the ER-Golgi pathway
NOP53	Ribosome assembly cofactor
WDR74	WD repeat-containing protein 74
Translation deficit	Reduced protein synthesis in AD brain correlates with cognitive decline
Nucleolar stress	SURF6 downregulation triggers p53-dependent apoptosis 2
Tau pathology	Ribosome dysfunction contributes to tau-induced neurodegeneration
ER stress	Impaired ribosome biogenesis increases ER stress
Protein homeostasis	Defects in translation machinery disrupt proteostasis
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SURF6 — SURF6 Homolog

gene · 1172 words

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Pathway Diagram

graph TD
    SURF6["SURF6"]
    neurodegeneration["neurodegeneration"]
    SURF6 -->|"implicated_in"| neurodegeneration
    style SURF6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SURF6 in their description or question text

No additional research found