gene

STX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive coverage of STX2 (Syntaxin 2) in synaptic transmission, SNARE complex function, membrane fusion, and implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

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🧬 Gene Info

Gene Symbol	STX2
Full Name	Syntaxin 2
Chromosome	12q24.31
Function	is a member of the syntaxin family of SNARE (Soluble NSF Attachment Protein Receptor) proteins that mediate membrane fusion events in eukaryotic cells.
Primary Expression	both excitatory and inhibitory neurons - Synaptic localization: Primarily presynaptic, with some postsynaptic presence - Non-neuronal tissues:
Amino Acids	288 aa
UniProt ID	P32856
NCBI Gene ID	2054
Ensembl ID	ENSG00000120280
OMIM	132050
GeneCards	STX2
Human Protein Atlas	STX2
N-terminal domain (1-60)	Regulatory domain that interacts with munc18 proteins
SNARE domain (60-230)	The central coiled-coil domain that forms the SNARE complex
Linker region (230-265)	Flexible hinge region
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STX2 — AlphaFold P32856 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STX2 — Syntaxin 2

gene · 2774 words

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Pathway Diagram

graph TD
    STX2["STX2"]
    neurodegeneration["neurodegeneration"]
    STX2 -->|"implicated_in"| neurodegeneration
    style STX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning STX2 in their description or question text

No additional research found