gene

STK3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about STK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

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🧬 Gene Info

Gene Symbol	STK3
Full Name	Serine/Threonine Kinase 3 (Mammalian STE20-like Kinase 2)
Chromosome	8q22.2
Protein Type	Serine/Threonine Kinase
Function	encodes a 491 amino acid serine/threonine kinase that functions as a core upstream kinase of the Hippo signaling pathway.
Primary Expression	neural progenitors and differentiating neurons
Amino Acids	491 aa
Exons	11
Ensembl ID	ENSG00000104375
GeneCards	STK3
Human Protein Atlas	STK3
RASSF1A	Paradoxically both activates (via SARAH binding) and prevents caspase-3 cleavage
[PP2A](/entities/pp2a) phosphatases	Dephosphorylate T180
AKT	Phosphorylates STK3 at T117 and T384, inhibiting kinase activity — providing crosstalk with PI3K/AKT survival signaling
YAP inactivation	STK3-LATS-YAP cascade reduces expression of pro-survival genes in nigral neurons
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STK3

gene · 1191 words

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Pathway Diagram

graph TD
    STK3["STK3"]
    neurodegeneration["neurodegeneration"]
    STK3 -->|"implicated_in"| neurodegeneration
    style STK3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning STK3 in their description or question text

No additional research found