| Gene Symbol | STK3 |
| Full Name | Serine/Threonine Kinase 3 (Mammalian STE20-like Kinase 2) |
| Chromosome | 8q22.2 |
| Protein Type | Serine/Threonine Kinase |
| Function | encodes a 491 amino acid serine/threonine kinase that functions as a core upstream kinase of the Hippo signaling pathway. |
| Primary Expression | neural progenitors and differentiating neurons |
| Amino Acids | 491 aa |
| Exons | 11 |
| Ensembl ID | ENSG00000104375 |
| GeneCards | STK3 |
| Human Protein Atlas | STK3 |
| RASSF1A | Paradoxically both activates (via SARAH binding) and prevents caspase-3 cleavage |
| [PP2A](/entities/pp2a) phosphatases | Dephosphorylate T180 |
| AKT | Phosphorylates STK3 at T117 and T384, inhibiting kinase activity — providing crosstalk with PI3K/AKT survival signaling |
| YAP inactivation | STK3-LATS-YAP cascade reduces expression of pro-survival genes in nigral neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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