entity

ST2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ST2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections
2Hypotheses
1Analyses
0Outgoing
3Incoming
0Experiments
1Debates

No AI portrait yet

Wiki Pages (4)

Knowledge base pages for this entity

KAT7 — Lysine Acetyltransferase 7 (HBO1/MYST2)

gene · 994 words

IL-33/ST2 Modulation Therapy for Neurodegeneration

therapeutic · 778 words

HS3ST2 Gene

gene · 641 words

IL1RL1 Protein (ST2)

protein · 599 words

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (3)

SourceRelationTypeStr
NLRP3activatesgene0.60
NLRP3part_ofgene0.50
HDAC2co_associated_withgene0.30

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site 0.415 neurodegeneration How does HDAC1/2 deletion specifically e
IL-33/ST2 Axis Augmentation for Synaptic Protection 0.105 neurodegeneration Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study shows HDAC1/2 deletion improves amyloid clearance and cognition,

closed · Rounds: 4 · Score: 0.95 · 2026-04-13

Related Research

Hypotheses and analyses mentioning ST2 in their description or question text

No additional research found