Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SNX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SNX3 |
| Full Name | Sorting Nexin 3 |
| Chromosome | 6q21 |
| Function | SNX3 is a peripheral membrane protein that localizes to early endosomes and functions in several key capacities: |
| UniProt ID | O60443 |
| NCBI Gene ID | 8724 |
| Ensembl ID | ENSG00000128967 |
| OMIM | 604767 |
| GeneCards | SNX3 |
| Human Protein Atlas | SNX3 |
| VPS26/VPS29/VPS35 complex | SNX3 bridges the core retromer complex with cargo proteins |
| Cargo recognition | Mediates selective retrieval of cargo from endosomes to the trans-Golgi network (TGN) or plasma membrane |
| WASH complex interaction | Coordinates with the WASH complex for actin remodeling |
| PI3P binding | Binds specifically to phosphatidylinositol-3-phosphate (PI3P) on early endosomal membranes |
| Membrane targeting | This binding targets SNX3 to endosomal compartments |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SNX3["SNX3"]
style SNX3 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
BST_2(["BST-2"])
neurodegeneration["neurodegeneration"]
SNX3 -->|"regulates"| BST_2
SNX3 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class BST_2 protein
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SNX3 | data_in | dataset_row | 0.00 |
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| BST-2 | regulates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SNX3 | data_in | dataset_row | 0.00 |
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SNX3 in their description or question text
No additional research found