gene

SLIT2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLIT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SLIT2 encodes a secreted axon guidance molecule that binds to ROBO receptors, mediating repulsive axon guidance, neuronal migration, and synaptic development. Important in neurodegeneration and cancer.

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🧬 Gene Info

Gene Symbol	SLIT2
Full Name	Slit Guidance Ligand 2
Chromosome	4p15.1
Function	is a secreted protein that functions as the ligand for Roundabout (ROBO) receptors, mediating repulsive axon guidance and cell migration during development.
Primary Expression	hippocampal neurons
Amino Acids	1529 aa
Exons	36
GeneCards	SLIT2
Human Protein Atlas	SLIT2
N-terminal signal peptide	Directs secretion
Leucine-rich repeats (LRRs)	Mediate ROBO binding (approximately 20 LRRs in the N-terminal region)
C-terminal cysteine-rich domain	Receptor interaction and dimerization
C-terminal coiled-coil region	Protein-protein interactions
Isoform 1	Full-length (1529 aa) - predominant brain expression
Isoform 2	Truncated N-terminus - secreted form
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLIT2 — Slit Guidance Ligand 2

gene · 2026 words

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Pathway Diagram

graph TD
    SLIT2["SLIT2"]
    neurodegeneration["neurodegeneration"]
    SLIT2 -->|"implicated_in"| neurodegeneration
    style SLIT2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLIT2 in their description or question text

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