Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLIT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SLIT1 is a large extracellular matrix protein that functions as a ligand for ROBO receptors, playing crucial roles in axon guidance, neuronal migration, and synaptic development.
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| Gene Symbol | SLIT1 |
| Full Name | Slit Guidance Ligand 1 |
| Chromosome | 10q24.1 |
| Protein Family | Slit family |
| Function | encodes a large secreted extracellular matrix protein that functions as the primary ligand for Roundabout (ROBO) receptors. |
| Amino Acids | 564 aa |
| Exons | 36 |
| UniProt ID | Q9NY64 |
| NCBI Gene ID | 6588 |
| Ensembl ID | ENSG00000107829 |
| GeneCards | SLIT1 |
| Human Protein Atlas | SLIT1 |
| Large coding region | Single large exon encoding the majority of the protein |
| Multiple protein domains | Including leucine-rich repeats (LRRs), EGF-like domains, and laminin G domains |
| Alternative splicing | Various isoforms with different expression patterns |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLIT1["SLIT1"]
neurodegeneration["neurodegeneration"]
SLIT1 -->|"implicated_in"| neurodegeneration
style SLIT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLIT1 in their description or question text
No additional research found