Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about slc2a3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC2A3 |
| Full Name | Solute Carrier Family 2 Member 3 (GLUT3) |
| Chromosome | 12p13.31 |
| Protein Family | Major Facilitator Superfamily (MFS) |
| Function | encodes GLUT3 (Glucose Transporter 3), a high-affinity glucose transporter with the highest uptake capacity among GLUT family members |
| Primary Expression | neurons, particularly in regions with high metabolic demand including the cerebral cortex, hippocampus, and cerebellar Purkinje cells |
| UniProt ID | P11166 |
| NCBI Gene ID | 6503 |
| Ensembl ID | ENSG00000146670 |
| OMIM | 138170 |
| GeneCards | SLC2A3 |
| Human Protein Atlas | SLC2A3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
SLC2A3["SLC2A3"] -->|"promotes"| glucose_uptake["glucose uptake"]
SLC2A3["SLC2A3"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
GLUCOSE_UPTAKE["GLUCOSE UPTAKE"] -->|"expressed in"| MUSCLE["MUSCLE"]
TUG["TUG"] -->|"regulates"| Glucose_Uptake["Glucose Uptake"]
Insulin_Stimulated_TUG_Cleavag["Insulin-Stimulated TUG Cleavage"] -->|"upregulates"| Glucose_Uptake["Glucose Uptake"]
ASPSCR1["ASPSCR1"] -->|"promotes"| Glucose_Uptake["Glucose Uptake"]
style SLC2A3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style glucose_uptake fill:#5d4400,stroke:#333,color:#e0e0e0
style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
style GLUCOSE_UPTAKE fill:#006494,stroke:#333,color:#e0e0e0
style MUSCLE fill:#006494,stroke:#333,color:#e0e0e0
style TUG fill:#006494,stroke:#333,color:#e0e0e0
style Glucose_Uptake fill:#5d4400,stroke:#333,color:#e0e0e0
style Insulin_Stimulated_TUG_Cleavag fill:#1b5e20,stroke:#333,color:#e0e0e0
style ASPSCR1 fill:#006494,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SLC2A3 | data_in | dataset_row | 0.00 |
| glucose uptake | promotes | process | 0.90 |
| Synaptic Glucose Uptake | regulates | process | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SLC2A3 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.829
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning slc2a3 in their description or question text
No additional research found