protein

SK4PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SK4PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SK4 is uniquely expressed in non-neuronal cells, particularly immune cells and erythrocytes, where it fulfills essential physiological functions.

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🔬 Protein Info

Gene Symbol	SK4PROTEIN
Protein Type	Channel
Function	is an intermediate-conductance calcium-activated potassium channel encoded by the KCNN4 gene.
Primary Expression	non-neuronal cells, particularly immune cells and erythrocytes, where it fulfills essential physiological functions
Subcellular Localization	** \| Plasma membrane \|
Molecular Weight	48 kDa
Amino Acids	427 aa
GeneCards	SK4PROTEIN
Human Protein Atlas	SK4PROTEIN
S1-S4	Four transmembrane helices form a voltage sensor-like domain, but SK4 does not sense voltage. These helices are structural rather than functional.
S5-S6	The pore-forming helices that contain the potassium selectivity filter (sequence: GYG)
P-loop (H5)	The pore loop between S5 and S6 that contains the selectivity filter and determines K⁺ specificity
Calmodulin binding domain	Located in the cytoplasmic C-terminal tail (residues ~360-427)
Calcium sensing	Each channel subunit binds one calmodulin molecule
Activation mechanism	Ca²⁺-calmodulin binds to the C-terminal domain, inducing a conformational change that opens the channel
Associated Diseases	neurodegeneration
Known Drugs/Compounds	Ferroptosis, LAT1
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

sk4-protein

protein · 1994 words

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Pathway Diagram

graph TD
    SK4PROTEIN["SK4PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SK4PROTEIN -->|"implicated_in"| neurodegeneration
    style SK4PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning SK4PROTEIN in their description or question text

No additional research found