| Gene Symbol | SK4PROTEIN |
| Protein Type | Channel |
| Function | is an intermediate-conductance calcium-activated potassium channel encoded by the KCNN4 gene. |
| Primary Expression | non-neuronal cells, particularly immune cells and erythrocytes, where it fulfills essential physiological functions |
| Subcellular Localization | ** | Plasma membrane | |
| Molecular Weight | 48 kDa |
| Amino Acids | 427 aa |
| GeneCards | SK4PROTEIN |
| Human Protein Atlas | SK4PROTEIN |
| S1-S4 | Four transmembrane helices form a voltage sensor-like domain, but SK4 does not sense voltage. These helices are structural rather than functional. |
| S5-S6 | The pore-forming helices that contain the potassium selectivity filter (sequence: GYG) |
| P-loop (H5) | The pore loop between S5 and S6 that contains the selectivity filter and determines K⁺ specificity |
| Calmodulin binding domain | Located in the cytoplasmic C-terminal tail (residues ~360-427) |
| Calcium sensing | Each channel subunit binds one calmodulin molecule |
| Activation mechanism | Ca²⁺-calmodulin binds to the C-terminal domain, inducing a conformational change that opens the channel |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | Ferroptosis, LAT1 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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