gene

SCO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SCO2 encodes a mitochondrial copper chaperone essential for cytochrome c oxidase (Complex IV) assembly, mutations cause Leigh syndrome, cardiomyopathy, and severe metabolic disorders

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🧬 Gene Info

Gene Symbol	SCO2
Full Name	Cytochrome c Oxidase Assembly Factor SCO2
Aliases	Complex IV
Function	encodes a mitochondrial protein essential for the assembly of cytochrome c oxidase (COX), also known as Complex IV of the mitochondrial respiratory chain.
Subcellular Localization	the mitochondrial matrix:
Molecular Weight	29 kDa
Amino Acids	262 aa
Ensembl ID	ENSG00000130489
GeneCards	SCO2
Human Protein Atlas	SCO2
Inner membrane association	Partially associated with the inner membrane near assembly intermediates
Assembly complexes	Part of larger COX assembly intermediates
Onset	Presents in the first months of life
Symptoms	Severe cardiomyopathy, lactic acidosis, failure to thrive
Outcome	Typically fatal within the first year of life
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCO2 — Cytochrome c Oxidase Assembly Factor SCO2

gene · 1543 words

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ESCO2 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2

gene · 711 words

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Pathway Diagram

graph TD
    SCO2["SCO2"]
    neurodegeneration["neurodegeneration"]
    SCO2 -->|"implicated_in"| neurodegeneration
    style SCO2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCO2 in their description or question text

No additional research found