| Gene Symbol | ESCO2 |
| Full Name | Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 |
| Aliases | Page for ESCO2 |
| Protein Type | Transferase |
| Function | is an S-phase specific lysine acetyltransferase that acetylates the SMC3 subunit of the cohesin complex, a modification essential for establishing sister chromatid cohesion during DNA replication. |
| Ensembl ID | ENSG00000174607 |
| GeneCards | ESCO2 |
| Human Protein Atlas | ESCO2 |
| Establishes cohesion | Creates stable sister chromatid linkages during S phase |
| Prevents premature separation | Protects cohesin from WAPL-mediated release |
| Ensures faithful segregation | Enables accurate chromosome distribution at anaphase[@unal2008] |
| Prenatal growth deficiency | Severe growth restriction beginning in utero |
| Limb reductions | Tetraphocomelia (severe limb shortening) or milder limb defects |
| Craniofacial abnormalities | Cleft lip/palate, hypertelorism, micrognathia |
| Chromosomal instability | Premature centromere separation (PCS) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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