protein

RRM2BPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RRM2BPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The RRM2B protein (also known as p53R2 or ribonucleotide reductase small subunit 2-like) is a critical enzyme involved in deoxyribonucleotide (dNTP) synthesis and mitochondrial DNA maintenance.

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🔬 Protein Info

Gene Symbol	RRM2BPROTEIN
Protein Type	Enzyme
Function	is a critical enzyme involved in deoxyribonucleotide (dNTP) synthesis and mitochondrial DNA maintenance.
Subcellular Localization	Signal**: Facilitates import to nucleus for DNA repair functions ### Enzymatic
Molecular Weight	37 kDa
Amino Acids	353 aa
GeneCards	RRM2BPROTEIN
Human Protein Atlas	RRM2BPROTEIN
RRM1 (Large Subunit)	Contains the catalytic site and allosteric regulatory domains, performing the actual reduction of ribonucleotides to deoxyribonucleotides.
RRM2B (Small Subunit)	Contains the diiron-carboxylate active site that generates a tyrosyl free radical essential for catalysis. The subunit is essential for stabilizing the RNR complex and maintaining enzymatic activity.
N-terminal Domain	Contains the diiron-carboxylate site essential for tyrosyl radical generation
C-terminal Region	Mediates interaction with RRM1 and complex formation
Iron-Sulfur Cluster	[2Fe-2S] center required for catalytic activity
Nuclear Localization Signal	Facilitates import to nucleus for DNA repair functions
mtDNA Replication	Provides dNTPs essential for mtDNA replication, particularly during repair and replication cycles
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

rrm2b-protein

protein · 1520 words

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Pathway Diagram

graph TD
    RRM2BPROTEIN["RRM2BPROTEIN"]
    neurodegeneration["neurodegeneration"]
    RRM2BPROTEIN -->|"implicated_in"| neurodegeneration
    style RRM2BPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning RRM2BPROTEIN in their description or question text

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