| Gene Symbol | RRM2BPROTEIN |
| Protein Type | Enzyme |
| Function | is a critical enzyme involved in deoxyribonucleotide (dNTP) synthesis and mitochondrial DNA maintenance. |
| Subcellular Localization | Signal**: Facilitates import to nucleus for DNA repair functions ### Enzymatic |
| Molecular Weight | 37 kDa |
| Amino Acids | 353 aa |
| GeneCards | RRM2BPROTEIN |
| Human Protein Atlas | RRM2BPROTEIN |
| RRM1 (Large Subunit) | Contains the catalytic site and allosteric regulatory domains, performing the actual reduction of ribonucleotides to deoxyribonucleotides. |
| RRM2B (Small Subunit) | Contains the diiron-carboxylate active site that generates a tyrosyl free radical essential for catalysis. The subunit is essential for stabilizing the RNR complex and maintaining enzymatic activity. |
| N-terminal Domain | Contains the diiron-carboxylate site essential for tyrosyl radical generation |
| C-terminal Region | Mediates interaction with RRM1 and complex formation |
| Iron-Sulfur Cluster | [2Fe-2S] center required for catalytic activity |
| Nuclear Localization Signal | Facilitates import to nucleus for DNA repair functions |
| mtDNA Replication | Provides dNTPs essential for mtDNA replication, particularly during repair and replication cycles |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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