Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPL18 |
| Function | RPL18 is a component of the 60S ribosomal subunit involved in protein synthesis. |
| Primary Expression | neurons and glial cells, with high expression in hippocampus and [cereb |
| Ensembl ID | ENSG00000109180 |
| GeneCards | RPL18 |
| Human Protein Atlas | RPL18 |
| Synaptic protein synthesis deficits | RPL18 dysfunction reduces the capacity for activity-dependent synaptic protein synthesis |
| Local translation impairment | Dendritic and axonal local translation, essential for synaptic plasticity, is compromised |
| Receptor trafficking disruptions | Synaptic receptor expression and cycling require ongoing protein synthesis |
| Associated Diseases | Aortic Valve Calcification |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RPL18["RPL18 Gene"]
RIB_BIOGEN["Ribosome Biogenesis"]
PROT_SYNTH["Protein Synthesis"]
ER_STRESS["ER Stress Response"]
UPR["Unfolded Protein Response"]
CHOP["CHOP Transcription Factor"]
APOPTOSIS["Neuronal Apoptosis"]
MITOCH_DYS["Mitochondrial Dysfunction"]
OXIDATIVE["Oxidative Stress"]
CALCIUM["Calcium Dysregulation"]
AVC["Aortic Valve Calcification"]
VASCULAR["Vascular Dysfunction"]
NEUROINFLAM["Neuroinflammation"]
NEURODEGENERATION["Neurodegeneration"]
P53["p53 Pathway"]
AUTOPHAGY["Autophagy Impairment"]
RPL18 -->|"encodes"| RIB_BIOGEN
RIB_BIOGEN -->|"enables"| PROT_SYNTH
PROT_SYNTH -->|"dysfunction triggers"| ER_STRESS
ER_STRESS -->|"activates"| UPR
UPR -->|"prolonged activation"| CHOP
CHOP -->|"promotes"| APOPTOSIS
RPL18 -->|"mutations affect"| MITOCH_DYS
MITOCH_DYS -->|"generates"| OXIDATIVE
OXIDATIVE -->|"disrupts"| CALCIUM
CALCIUM -->|"triggers"| APOPTOSIS
RPL18 -->|"associated with"| AVC
AVC -->|"contributes to"| VASCULAR
VASCULAR -->|"impairs"| NEUROINFLAM
ER_STRESS -->|"activates"| P53
P53 -->|"impairs"| AUTOPHAGY
AUTOPHAGY -->|"accumulation leads to"| NEURODEGENERATION
APOPTOSIS -->|"causes"| NEURODEGENERATION
style RPL18 fill:#1a3a4a,stroke:#4fc3f7
style RIB_BIOGEN fill:#2a1a3a,stroke:#ce93d8
style PROT_SYNTH fill:#2a1a3a,stroke:#ce93d8
style ER_STRESS fill:#3a1a1a,stroke:#ef5350
style UPR fill:#3a1a1a,stroke:#ef5350
style CHOP fill:#3a1a1a,stroke:#ef5350
style APOPTOSIS fill:#3a1a1a,stroke:#ef5350
style MITOCH_DYS fill:#3a1a1a,stroke:#ef5350
style OXIDATIVE fill:#3a1a1a,stroke:#ef5350
style CALCIUM fill:#3a1a1a,stroke:#ef5350
style AVC fill:#3a2a1a,stroke:#ffa726
style VASCULAR fill:#3a1a1a,stroke:#ef5350
style NEUROINFLAM fill:#3a1a1a,stroke:#ef5350
style NEURODEGENERATION fill:#3a2a1a,stroke:#ffa726
style P53 fill:#2a1a3a,stroke:#ce93d8
style AUTOPHAGY fill:#3a1a1a,stroke:#ef5350| Target | Relation | Type | Str |
|---|---|---|---|
| Aortic Valve Calcification | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPL18 in their description or question text
No additional research found