Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RNF182: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RNF182 |
| Full Name | Ring Finger Protein 182 |
| Chromosome | 6p21.1 |
| Protein Type | Ligase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | brain tissue, RNF182 has garnered significant attention for its involvement in neurodegenerative diseases, particularly Alzheimer's disease (AD) and H |
| Molecular Weight | 34 kDa |
| Amino Acids | 60 aa |
| UniProt ID | Q9Y2H9 |
| GeneCards | RNF182 |
| Human Protein Atlas | RNF182 |
| Monoubiquitination | Single ubiquitin addition, often regulating protein activity or localization |
| Polyubiquitin chains | K48-linked chains typically target proteins for proteasomal degradation, while K63-linked chains serve non-degradative functions including signaling, DNA repair, and autophagy regulation |
| Cerebellum | Present in Purkinje cells and cerebellar granule neurons |
| Substantia nigra | Dopaminergic neurons express RNF182 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RNF182["RNF182"]
neurodegeneration["neurodegeneration"]
RNF182 -->|"implicated_in"| neurodegeneration
style RNF182 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RNF182 in their description or question text
No additional research found